Learn more about common metastatic melanoma treatment options for patients with stage III or IV disease. Have stage three c metastic melonoma. Melanoma Staging What Each Diagnosis Reveals Definition and Prognosis From Stage 0 to Stage IV. Binimetinib MEK162 Target MEK Indication Melanoma and Colorectal Cancer. Introduction Brief Description. Binimetinib is an oral smallmolecule MEK inhibitor. The earliest stage of melanoma starts when melanocytes begin outofcontrol growth. Melanocytes are found between the outer layer of the skin the epidermis and the. ID no other information is captured. Accepting the NEJM cookie is.